Our Mission
The laboratory is interested in addressing basic and translational questions at the interface of RNA biology, hematopoiesis, immunology, and cancer with the goal of improving human health.
Based on recent work using therapeutic modulation of RNA splicing to enhance anti-tumor immunity, there are two related domains of work. These revolve around studies of RNA processing in the context of (1) regulating leukocyte development and function (2) cancer immunotherapy.
Our Laboratory
The lab is located in the Center for Clinical Sciences Research (CCSR) building in the heart of Stanford Medical School in sunny Palo Alto.
Our members
Sydney Lu, M.D. Ph.D.
Principal Investigator
Sydney Lu is a physician-scientist who leads a research group at Stanford Medical School, Division of Hematology, Department of Medicine.
We are hiring:
Postdoctoral fellow
Life Sciences Research Professional
Graduate research assistant
Our latest publications
Sekrecki M, Sekrecka A, Lattupally RR, Le K, Jin X, Mozes C, Dwyer BG, Zhuang Z, Romero BA, Pineda JMB, Cao X, Nguyen L, Chen V, Zhou CM, Wallace JA, Tanaka K, Tiwari C, Gabel A, Kim WJ, Stanley RF, Benbarche S, Thind J, Muruganandham A, Zhang TY, Greenberg PL, Gotlib JR, Mannis GN, Shomali W, Salmasi GG, Kuo CJ, Shanafelt TD, Singh I, Inoue D, Hansen FK, Gray NS, Van Rechem C, Fakhri B, Zhang X, Lu SX. Oncogenic SF3B1 mutations alter the splicing of mRNA noncoding regions to induce a novel therapeutic vulnerability. Blood. 2026 Apr 23;147(17):1941-1957. doi: 10.1182/blood.2025029972. PMID: 41587094
Lu SX, de Neef E, Thomas JD, Sabio E, Rousseau B, Gigoux M, Knorr DA, Greenbaum B, Elhanati Y, Hogg SJ, Chow A, Ghosh A, Xie A, Zmarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham BH, Shah H, Chowell D, Gabel AM, Shen Y, Liu J, Jin J, Rhodes MC, Taylor RE, Molina H, Wolchok J, Merghoub T, Diaz Jr. LA, Abdel-Wahab O, Bradley RK. Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell 2021 Jul 22;184(15):4032-4047.e31. DOI: 10.1016/j.cell.2021.05.038